Ledeboer M, Masclee A A, Jansen J B, Lamers C B
Department of Gastroenterology-Hepatology, University Hospital of Leiden, The Netherlands.
JPEN J Parenter Enteral Nutr. 1995 Jan-Feb;19(1):5-8. doi: 10.1177/014860719501900105.
The use of medium-chain triglycerides in diets is limited by the frequent occurrence of diarrhea or crampy abdominal pain. Because these symptoms may result from an accelerated transit time induced by medium-chain triglycerides, we investigated the effect of equimolar amounts of long-chain triglycerides and medium-chain triglycerides on small-bowel transit time in 10 healthy subjects.
Small-bowel transit time was measured by the lactulose hydrogen breath test after intraduodenal administration of lactulose.
Intraduodenal administration of 20 mmol of long-chain triglycerides per hour for 90 minutes did not alter small-bowel transit time compared with control (77 +/- 11 minutes vs 77 +/- 10 minutes, respectively), whereas intraduodenal infusion of an equimolar dose of medium-chain triglycerides significantly accelerated small-bowel transit time (59 +/- 6 minutes) compared with long-chain triglycerides and control (p < .05). In six individuals, small-bowel transit time was shorter during the administration of medium-chain triglycerides compared with control, and three of these subjects experienced abdominal symptoms. Plasma cholecystokinin levels increased significantly (p < .05) during the administration of long-chain triglycerides, from 2.6 +/- 0.3 pmol/L to a maximum of 4.3 +/- 0.6 pmol/L. No significant alterations were observed in plasma cholecystokinin levels during administration of medium-chain triglycerides or in the control experiment.
Although it significantly increases cholecystokinin secretion, the intraduodenal infusion of long-chain triglycerides does not affect small-bowel transit time, whereas the infusion of medium-chain triglycerides accelerates small-bowel transit time, independent of cholecystokinin.
中链甘油三酯在饮食中的应用受到腹泻或痉挛性腹痛频繁发生的限制。由于这些症状可能是由中链甘油三酯引起的转运时间加快所致，我们研究了等摩尔量的长链甘油三酯和中链甘油三酯对10名健康受试者小肠转运时间的影响。
通过十二指肠内给予乳果糖后用乳果糖氢呼气试验测量小肠转运时间。
每小时十二指肠内给予20 mmol长链甘油三酯，持续90分钟，与对照组相比，小肠转运时间未改变（分别为77±11分钟和77±10分钟），而十二指肠内输注等摩尔剂量的中链甘油三酯与长链甘油三酯组和对照组相比，显著加快了小肠转运时间（59±6分钟）（P<0.05）。在6名个体中，与对照组相比，中链甘油三酯给药期间小肠转运时间较短，其中3名受试者出现腹部症状。长链甘油三酯给药期间血浆胆囊收缩素水平显著升高（P<0.05），从2.6±0.3 pmol/L升至最高4.3±0.6 pmol/L。中链甘油三酯给药期间或对照实验中，血浆胆囊收缩素水平未观察到显著变化。
尽管十二指肠内输注长链甘油三酯可显著增加胆囊收缩素分泌，但不影响小肠转运时间，而输注中链甘油三酯可加快小肠转运时间，且与胆囊收缩素无关。
