Marciani M G, Maschio M C, Spanedda F, Gigli G L, Bassetti M A, Bernardi G
Clinica Neurologica, Università degli Studi di Roma Tor Vergata, Italia.
Neuropsychobiology. 1995;31(4):210-5. doi: 10.1159/000119196.
Seventeen epileptic patients suffering from generalized idiopathic epilepsy who underwent antiepileptic treatment with sodium valproate (NaVPA) for the first time were studied. The EEG was recorded at rest with eyes closed (EC), during blocking reaction, fixation and mental arithmetic tasks. The computerized EEG study, performed before and after therapy, utilized spectral analysis; data underwent statistical evaluation including ANOVA and correlation analysis. Before NaVPA therapy, a significant decrease of beta 1 and beta 2 relative power, compared with control subjects, was observed in epileptic patients at rest with EC, whereas fast activity increased during mental tasks. After treatment, no significant variations in fast activity were observed during tasks, with a pattern similar to that observed in the control population. Therefore, considering the effect of NaVPA primarily on fast activity, which reflects rather well preserved mental functioning processes, it is possible to hypothesize that the drug interferes positively with mental activities.
对17例首次接受丙戊酸钠（NaVPA）抗癫痫治疗的全身性特发性癫痫患者进行了研究。在闭眼静息（EC）状态、阻断反应、注视和心算任务期间记录脑电图。在治疗前后进行的计算机化脑电图研究采用了频谱分析；数据进行了包括方差分析和相关分析在内的统计评估。在NaVPA治疗前，与对照组相比，癫痫患者在EC静息状态下观察到β1和β2相对功率显著降低，而在心理任务期间快波活动增加。治疗后，在任务期间未观察到快波活动的显著变化，其模式与对照组人群中观察到的相似。因此，考虑到NaVPA主要对快波活动的影响，而快波活动较好地反映了保存完好的心理功能过程，可以推测该药物对心理活动有积极影响。
