Marciani M G, Maschio M, Spanedda F, Caltagirone C, Gigli G L, Bernardi G
Clinica Neurologica, Università degli Studi di Roma, Tor Vergata, Italy.
Int J Neurosci. 1994 May;76(1-2):131-40. doi: 10.3109/00207459408985998.
Computerized EEG study was performed on 39 healthy elderly subjects (50-90 years), divided into two cohorts of increasing age (old, older) and on a group of 21 young controls. The EEG was recorded at rest, with eyes closed (EC) and during blocking reaction (BR), fixation (FIX) and mental arithmetic (MA) tasks. At rest with EC, the only significant variation was an increase of beta 1 relative power in old subjects which was positively correlated with age. During the performance of the mental tasks, in the elderly population when compared to young controls, the slow activity decreased slightly or was not significantly modified, while the alpha reactivity progressively decreased, showing a negative correlation with age in the older group. Beta 2 increased significantly in elderly subjects during BR and FIX but such change was less consistent with increasing age. Data show that at rest, the EEG in the elderly population differs only from that of young controls by showing a more pronounced fast activity, while only during mental processes is it possible to evidence changes that can be utilized as physiological "markers" of normal aging.
对39名健康老年人（50 - 90岁）进行了计算机脑电图研究，这些老年人被分为年龄递增的两个队列（老年组、高龄组），并与一组21名年轻对照者进行对比。脑电图记录在静息状态下进行，分别为闭眼（EC）以及在阻断反应（BR）、注视（FIX）和心算（MA）任务期间。在闭眼静息状态下，唯一显著的变化是老年受试者中β1相对功率增加，且与年龄呈正相关。在执行心理任务期间，与年轻对照者相比，老年人群中的慢波活动略有下降或无显著变化，而α波反应性逐渐降低，在高龄组中与年龄呈负相关。在BR和FIX期间，老年受试者的β2显著增加，但这种变化与年龄增长的一致性较差。数据表明，在静息状态下，老年人群的脑电图与年轻对照者的差异仅在于表现出更明显的快波活动，而只有在心理过程中才有可能证明那些可作为正常衰老生理“标志物”的变化。
