Fricchione G L, Carbone L, Bennett W I
Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Psychiatr Clin North Am. 1995 Jun;18(2):363-78.
Many medical and neurologic disorders cause psychosis with delusions. The pathophysiology of this final common pathway may shed light on idiopathic psychotic disorders such as schizophrenia. By focusing on the "basal ganglia-thalamocortical" and "corticostriatal-thalamocortical" loops that connect limbically related cortical regions with the mesolimbic-mesostriatal dopamine system we can view the neural network that may produce delusional thinking when its restitutive function fails. Given its importance in the memory system of the medial temporal lobe, as the recipient of the emotional valencing from the amygdala, and as a key "loop" structure for cognitive functional integrity, the hippocampus may be a nodal area in the development of rational as opposed to delusional thinking.
许多医学和神经系统疾病会导致伴有妄想的精神病。这一最终共同通路的病理生理学可能有助于揭示诸如精神分裂症等特发性精神病性障碍。通过关注连接边缘相关皮质区域与中脑边缘 - 中脑纹状体多巴胺系统的“基底神经节 - 丘脑皮质”和“皮质纹状体 - 丘脑皮质”环路，我们可以看到当其恢复功能失败时可能产生妄想思维的神经网络。鉴于海马体在内侧颞叶记忆系统中的重要性，作为杏仁核情感效价的接受者，以及作为认知功能完整性的关键“环路”结构，海马体可能是理性思维而非妄想思维发展中的一个节点区域。
