Donoso A, Lillo R, Quiroz M, Rojas A
Departamento de Neurología y Neurocirugía, Facultad de Medicina (Campus Norte), Universidad de Chile, Hospital José Joaquín Aguirre, Santiago.
Rev Med Chil. 1994 Dec;122(12):1408-12.
Six patients with primary degenerative dementias and frontal or frontotemporal hypoperfusion are reported. Five were diagnosed as Frontal Progressive Dementia (FPD), characterized by striking changes in personality and social behavior. The last patient had a progressive aphasia and a moderate cognitive impairment. We discuss the heterogeneity of FPD that includes Pick's disease, frontal lobe type dementia (Neary) and progressive subcortical gliosis. The usefulness of SPECT and the need of a brain bank are remarked.
报告了6例患有原发性退行性痴呆且存在额叶或额颞叶灌注不足的患者。其中5例被诊断为额颞叶进行性痴呆（FPD），其特征为性格和社交行为发生显著变化。最后1例患者患有进行性失语症和中度认知障碍。我们讨论了FPD的异质性，包括匹克氏病、额叶型痴呆（尼尔）和进行性皮质下胶质增生。强调了单光子发射计算机断层扫描（SPECT）的实用性以及脑库的必要性。
