萘啶酸对大肠杆菌紫外线照射后存活率的抑制作用。
Inhibition by nalidixic acid of post-uv survival of Escherichia coli.
作者信息
Nishida M, Nakamura N, Yielding K L
出版信息
Proc Soc Exp Biol Med. 1976 Feb;151(2):271-4. doi: 10.3181/00379727-151-39190.
Nalidixate inhibited the post-uv survival of E. coli B. TAU-bar and Ts-7, but not Bs-1 or B/r when included in the plating medium. Removal of the drug sensitivity by photoreactivation was consistent with pyrimidine dimers as the target for the effect. Nalidixate did not inhibit liquid-holding recovery from uv when included in the holding medium, but survival was inhibited if the drug was in the subsequent plating medium. In fact, there was an actual increase in the number of nonsurvivors due to the drug following a period of holding.
萘啶酸在平板培养基中时，可抑制大肠杆菌B的紫外线照射后存活。TAU-bar和Ts-7菌株对其敏感，但Bs-1或B/r菌株不敏感。通过光复活消除药物敏感性与嘧啶二聚体作为该效应的靶点一致。当萘啶酸存在于保存培养基中时，它不抑制紫外线照射后的液体保存复苏，但如果药物存在于随后的平板培养基中，则存活会受到抑制。实际上，经过一段时间的保存后，由于药物作用，非存活菌的数量实际上有所增加。
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