• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

萘啶酸对大肠杆菌K-12紫外线照射后恢复的抑制作用：recBC功能的需求

Nalidixic acid inhibition of post-ultraviolet recovery in Escherichia coli K-12: requirement for recBC function.

作者信息

Purdy M A, Yeilding K L

出版信息

Antimicrob Agents Chemother. 1976 Jul;10(1):182-4. doi: 10.1128/AAC.10.1.182.

DOI:10.1128/AAC.10.1.182
PMID:791087
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC429711/
Abstract

Various repair-deficient mutants of Escherichia coli K-12 were tested for the impairment of post-ultraviolet survival by nalidixic acid. These studies have shown that the target of this nalidixic acid effect is dictated by the recB and recC genes and may be due to the binding of nalidixic acid to exonuclease V. Furthermore, this effect cannot be correlated with either recombination proficiency or excision repair alone.

摘要

对大肠杆菌K-12的各种修复缺陷型突变体进行了萘啶酸对紫外线后存活损伤的测试。这些研究表明，萘啶酸这种效应的靶点由recB和recC基因决定，可能是由于萘啶酸与核酸外切酶V结合所致。此外，这种效应不能单独与重组能力或切除修复相关联。

相似文献

1
Nalidixic acid inhibition of post-ultraviolet recovery in Escherichia coli K-12: requirement for recBC function.萘啶酸对大肠杆菌K-12紫外线照射后恢复的抑制作用：recBC功能的需求
Antimicrob Agents Chemother. 1976 Jul;10(1):182-4. doi: 10.1128/AAC.10.1.182.
2
Survival of recombination-deficient mutants of Escherichia coli during incubation with nalidixic acid.大肠杆菌重组缺陷型突变体在与萘啶酸孵育期间的存活情况。
J Bacteriol. 1978 Jun;134(3):1195-8. doi: 10.1128/jb.134.3.1195-1198.1978.
3
Stability of DNA in dark-repair mutants of Escherichia coli B treated with nalidixic acid.用萘啶酸处理的大肠杆菌B暗修复突变体中DNA的稳定性
J Gen Microbiol. 1970 Apr;61(1):21-5. doi: 10.1099/00221287-61-1-21.
4
Escherichia coli recBC deletion mutants.大肠杆菌recBC缺失突变体
J Bacteriol. 1984 Nov;160(2):788-91. doi: 10.1128/jb.160.2.788-791.1984.
5
Genetic analysis of the requirements for SOS induction by nalidixic acid in Escherichia coli.大肠杆菌中萘啶酸诱导SOS反应的需求的遗传分析。
Gene. 2005 Aug 15;356:69-76. doi: 10.1016/j.gene.2005.04.029.
6
Enhancement of post-ultraviolet killing in Escherichia coli K-12 through the action of gyrase inhibitors: evidence for associated gyrase-recBC deoxyribonuclease function.通过拓扑异构酶抑制剂的作用增强大肠杆菌K-12紫外线照射后的杀伤效果：拓扑异构酶-recBC脱氧核糖核酸酶相关功能的证据
Antimicrob Agents Chemother. 1979 Sep;16(3):247-51. doi: 10.1128/AAC.16.3.247.
7
Inhibition by nalidixic acid of post-uv survival of Escherichia coli.萘啶酸对大肠杆菌紫外线照射后存活率的抑制作用。
Proc Soc Exp Biol Med. 1976 Feb;151(2):271-4. doi: 10.3181/00379727-151-39190.
8
Effect of inhibitors of DNA synthesis of UV-sensitive derivatives of Escherichia coli strain K-12.大肠杆菌K - 12紫外线敏感衍生物DNA合成抑制剂的作用
Mutat Res. 1970 Feb;9(2):149-54. doi: 10.1016/0027-5107(70)90053-9.
9
Differential thermolability of exonuclease and endonuclease activities of the recBC nuclease isolated from thermosensitive recB and recC mutants.从温度敏感型recB和recC突变体中分离出的recBC核酸酶的核酸外切酶和核酸内切酶活性的差异热稳定性。
J Bacteriol. 1974 Dec;120(3):1219-22. doi: 10.1128/jb.120.3.1219-1222.1974.
10
Genetic control of damage-inducible restriction alleviation in Escherichia coli K12: an SOS function not repressed by lexA.大肠杆菌K12中损伤诱导性限制缓解的遗传控制：一种不受lexA抑制的SOS功能。
Mol Gen Genet. 1984;197(2):297-303. doi: 10.1007/BF00330977.

引用本文的文献

1
Inhibition of Micrococcus luteus DNA topoisomerase I by UV photoproducts.紫外线光产物对藤黄微球菌DNA拓扑异构酶I的抑制作用。
Proc Natl Acad Sci U S A. 1983 Apr;80(7):1787-91. doi: 10.1073/pnas.80.7.1787.
2
Biology of bacterial deoxyribonucleic acid topoisomerases.细菌脱氧核糖核酸拓扑异构酶的生物学
Microbiol Rev. 1984 Dec;48(4):273-89. doi: 10.1128/mr.48.4.273-289.1984.
3
Enhancement of post-ultraviolet killing in Escherichia coli K-12 through the action of gyrase inhibitors: evidence for associated gyrase-recBC deoxyribonuclease function.通过拓扑异构酶抑制剂的作用增强大肠杆菌K-12紫外线照射后的杀伤效果：拓扑异构酶-recBC脱氧核糖核酸酶相关功能的证据
Antimicrob Agents Chemother. 1979 Sep;16(3):247-51. doi: 10.1128/AAC.16.3.247.

本文引用的文献

1
Three loci in Escherichia coli K-12 that control the excision of pyrimidine dimers and certain other mutagen products from DNA.大肠杆菌K-12中控制从DNA切除嘧啶二聚体和某些其他诱变产物的三个基因座。
Genetics. 1966 Jun;53(6):1119-36. doi: 10.1093/genetics/53.6.1119.
2
Analysis of DNA polymerases II and 3 in mutants of Escherichia coli thermosensitive for DNA synthesis.对大肠杆菌中对DNA合成温度敏感的突变体的DNA聚合酶II和3的分析。
Proc Natl Acad Sci U S A. 1971 Dec;68(12):3150-3. doi: 10.1073/pnas.68.12.3150.
3
Effect of nalidixic acid on semionservative replication and repair synthesis after ultraviolet irradiation in Escherichia coli.萘啶酸对大肠杆菌紫外线照射后半保留复制及修复合成的影响。
J Bacteriol. 1971 Mar;105(3):908-12. doi: 10.1128/jb.105.3.908-912.1971.
4
Genetic location of certain mutations conferring recombination deficiency in Escherichia coli.大肠杆菌中某些导致重组缺陷的突变的基因定位。
J Bacteriol. 1969 Jan;97(1):244-9. doi: 10.1128/jb.97.1.244-249.1969.
5
Mechanism of action of nalidixic acid on Escherichia coli. Vi. Cell-free studies.萘啶酸对大肠杆菌的作用机制。六、无细胞研究。
J Bacteriol. 1969 Jan;97(1):230-6. doi: 10.1128/jb.97.1.230-236.1969.
6
Studies on the mode of action of nalidixic acid.萘啶酸作用模式的研究。
Eur J Biochem. 1972 Feb 15;25(2):359-65. doi: 10.1111/j.1432-1033.1972.tb01704.x.
7
Selective inhibition of semiconservative DNA synthesis by nalidixic acid in permeabilized bacteria.萘啶酸对通透化细菌中半保留DNA合成的选择性抑制作用。
Biochim Biophys Acta. 1974 May 17;349(2):271-4. doi: 10.1016/0005-2787(74)90089-6.
8
Purification and properties of the recBC DNase of Escherichia coli K-12.大肠杆菌K-12的recBC核酸酶的纯化及性质
J Biol Chem. 1972 Mar 25;247(6):1849-60.
9
The isolation and characterization from Escherichia coli of an adenosine triphosphate-dependent deoxyribonuclease directed by rec B, C genes.由rec B、C基因指导的三磷酸腺苷依赖性脱氧核糖核酸酶从大肠杆菌中的分离与鉴定。
J Biol Chem. 1971 Nov;246(21):6543-55.
10
Studies on the mechanism of action of nalidixic acid.萘啶酸作用机制的研究。
Antimicrob Agents Chemother. 1973 Oct;4(4):479-86. doi: 10.1128/AAC.4.4.479.