Kofke W A, Brauer P, Policare R, Penthany S, Barker D, Horton J
Department of Anesthesiology/Critical Care Medicine 15241, USA.
Stroke. 1995 Sep;26(9):1603-6. doi: 10.1161/01.str.26.9.1603.
Transcranial Doppler ultrasonography has been reported to reflect changes in cerebral blood flow (CBF) with the use of radioactive tracer techniques, which are weighted to measure primarily cortical structures. We tested the hypothesis that changes in transcranial Doppler ultrasonography would reflect changes in CBF in the middle cerebral artery vascular territory with the use of stable xenon-enhanced CT to assess CBF during carotid occlusion.
Thirty-one conscious patients underwent balloon test occlusion of the internal carotid artery and transcranial Doppler ultrasonography and xenon-enhanced CT assessment of blood flow velocity and CBF, respectively, of the middle cerebral artery and its distribution during balloon test occlusion.
A significant correlation was seen between the change in CBF and the change in blood flow velocity for both brain levels at which CBF was determined (P < .0001). The average change in blood flow velocity was -13.4%, and the change in CBF was -15.1% and -17.7% at the two anatomic levels examined.
The data indicate that changes in blood flow velocity generally reflect changes in CBF throughout the middle cerebral artery vascular territory with abrupt occlusion of the internal carotid artery in unanesthetized humans.
经颅多普勒超声检查已被报道可利用放射性示踪技术反映脑血流量（CBF）的变化，这些技术主要用于测量皮质结构。我们检验了这样一个假设，即经颅多普勒超声检查的变化能够反映大脑中动脉血管区域的CBF变化，为此我们使用稳定氙增强CT在颈动脉闭塞期间评估CBF。
31名清醒患者分别接受了颈内动脉球囊试验闭塞、经颅多普勒超声检查以及氙增强CT对大脑中动脉及其在球囊试验闭塞期间的分布区域的血流速度和CBF的评估。
在确定了CBF的两个脑水平上，CBF变化与血流速度变化之间均存在显著相关性（P <.0001）。在所检查的两个解剖水平上，血流速度的平均变化为-13.4%，CBF的变化分别为-15.1%和-17.7%。
数据表明，在未麻醉的人体中，当颈内动脉突然闭塞时，血流速度的变化通常反映了整个大脑中动脉血管区域的CBF变化。
