Sowunmi A, Oduola A M
Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria.
Trans R Soc Trop Med Hyg. 1995 May-Jun;89(3):303-5. doi: 10.1016/0035-9203(95)90554-5.
The susceptibility in vivo of Plasmodium falciparum to mefloquine, mefloquine/sulfadoxine/pyrimethamine and chloroquine was investigated in 115 children with acute uncomplicated falciparum malaria. Susceptibility of P. falciparum isolates to mefloquine and chloroquine in vitro was also investigated. Mefloquine alone and mefloquine/sulfadoxine/pyrimethamine showed similar response rates and both reduced parasitaemia and fever more rapidly than chloroquine. Mefloquine also promptly reduced parasitaemia and fever within 48 h in all chloroquine treatment failures. In vitro, 10% of isolates showed reduced susceptibility to mefloquine and 18% were resistant to chloroquine. These results suggest that the addition of sulfadoxine/pyrimethamine does not have a significant therapeutic advantage over mefloquine alone in the treatment of acute uncomplicated falciparum malaria in children from this endemic area.
在115名患有急性非复杂性恶性疟原虫疟疾的儿童中，研究了恶性疟原虫在体内对甲氟喹、甲氟喹/磺胺多辛/乙胺嘧啶和氯喹的敏感性。还研究了恶性疟原虫分离株在体外对甲氟喹和氯喹的敏感性。单独使用甲氟喹和甲氟喹/磺胺多辛/乙胺嘧啶显示出相似的反应率，且两者比氯喹更迅速地降低了疟原虫血症和发热。在所有氯喹治疗失败的病例中，甲氟喹也在48小时内迅速降低了疟原虫血症和发热。在体外，10%的分离株对甲氟喹的敏感性降低，18%对氯喹耐药。这些结果表明，在治疗该流行地区儿童的急性非复杂性恶性疟原虫疟疾时，添加磺胺多辛/乙胺嘧啶相对于单独使用甲氟喹没有显著的治疗优势。
