Fortuin M, Maine N, Mendy M, Hall A, George M, Whittle H
International Agency for Research on Cancer, The Gambia Hepatitis Intervention Study, Banjul.
Trans R Soc Trop Med Hyg. 1995 May-Jun;89(3):326-9. doi: 10.1016/0035-9203(95)90564-2.
A nation-wide cross-sectional survey of 816 children 3-4 years old was carried out in The Gambia between September 1990 and July 1991 to assess the seroprevalence of antibodies against 3 diseases included in the expanded programme on immunization: measles, poliomyelitis and tetanus. Among 689 children whose records were available, 94.5% were fully immunized. Measles vaccine was administered to 97% of the children and 91% of these had detectable antibodies at the time of the survey. Antibodies against type 1 and type 3 polioviruses, after up to 6 doses of oral polio vaccine, were present in 88.1% and 89.3% of the children respectively. Ninety-seven percent of the children who had received 4 doses of diphtheria-pertussis-tetanus vaccine (DPT) and 91% of those who received 3 doses had detectable tetanus toxoid antibodies at the age of 3-4 years. This study shows that serological responses to EPI vaccines given in infancy persist at very satisfactory levels throughout early childhood.
1990年9月至1991年7月期间，在冈比亚对816名3至4岁儿童进行了一项全国性横断面调查，以评估扩大免疫规划中三种疾病（麻疹、脊髓灰质炎和破伤风）抗体的血清流行率。在有记录的689名儿童中，94.5% 已完全免疫。97% 的儿童接种了麻疹疫苗，其中91% 在调查时可检测到抗体。在接种了多达6剂口服脊髓灰质炎疫苗后，分别有88.1% 和89.3% 的儿童体内存在针对1型和3型脊髓灰质炎病毒的抗体。97% 接种了4剂白喉 - 百日咳 - 破伤风疫苗（DPT）的儿童以及91% 接种了3剂的儿童在3至4岁时可检测到破伤风类毒素抗体。这项研究表明，婴儿期接种的扩大免疫规划疫苗的血清学反应在整个幼儿期都保持在非常令人满意的水平。
