Gillespie S H, Kennedy N, Ngowi F I, Fomukong N G, al-Maamary S, Dale J W
Division of Communicable Diseases, Royal Free Hospital School of Medicine, London, UK.
Trans R Soc Trop Med Hyg. 1995 May-Jun;89(3):335-8. doi: 10.1016/0035-9203(95)90571-5.
Isolates of Mycobacterium tuberculosis from 88 patients with pulmonary tuberculosis in northern Tanzania were subjected to IS6110 restriction fragment length polymorphism (RFLP) analysis. Of 88 isolates, 73 fell into 11 groups of which 9 contained 2-5 isolates. Of 2 large homology groups one, group H (20 isolates), was isolated only from patients resident in the Kilimanjaro region, whereas 79% of isolates from other groups came from this region. A significant association (P = 0.023) was found between another group, M (24 isolates) and isolation from patients of the Masai tribe. The data from this pilot study support the idea that IS6110 RFLP analysis provides information which may be of value in the control of tuberculosis in Africa.
对来自坦桑尼亚北部88例肺结核患者的结核分枝杆菌分离株进行了IS6110限制性片段长度多态性（RFLP）分析。88株分离株中，73株分为11组，其中9组每组有2 - 5株分离株。在2个大的同源组中，H组（20株分离株）仅从乞力马扎罗地区的患者中分离得到，而其他组79%的分离株来自该地区。另一组M（24株分离株）与马赛部落患者的分离情况之间存在显著关联（P = 0.023）。这项初步研究的数据支持了这样一种观点，即IS6110 RFLP分析所提供的信息可能对非洲结核病的控制具有价值。
