Iushchuk N D, Tseneva G Ia, Alenushkina T V, Kuliashova L B
Zh Mikrobiol Epidemiol Immunobiol. 1995 May-Jun(3):106-8.
The effect of thymogen of the course of the infectious process caused by Y.enterocolitica serovars O3 and O9 in guinea pigs was studied. Thymogen was introduced into the animals on day 2 after their infection with Y.enterocolitica O3 and O9, introduced in daily injections of 10 micrograms/kg of body weight for 4 days. The evaluation of the characteristics of cell reactions in the lymphoid organs of the immune system (the thymus, the spleen, lymph nodes), nonspecific resistance and specific humoral response showed the effectiveness of using thymogen: this preparation produced an immunoregulatory effect in the infected animals; it decreased their polyclonal immune response, the development of autoimmune reactions and promoted the intensive development of delayed hypersensitivity (DH) after their enteral infection with Y.enterocolitica O9 and had no effect on the development of DH in the animals infected with Y.enterocolitica O3; it also enhanced the nonspecific resistance of the body, thus leading to a decrease in the dissemination of the infective agents in different organs and tissues and to their subsequent elimination from the body.
研究了胸腺生成素对豚鼠由小肠结肠炎耶尔森氏菌O3和O9血清型引起的感染过程的影响。在豚鼠感染小肠结肠炎耶尔森氏菌O3和O9后的第2天给动物注射胸腺生成素，以每天10微克/千克体重的剂量连续注射4天。对免疫系统淋巴器官（胸腺、脾脏、淋巴结）中细胞反应的特征、非特异性抵抗力和特异性体液反应的评估表明使用胸腺生成素是有效的：这种制剂在受感染的动物中产生免疫调节作用；它降低了它们的多克隆免疫反应、自身免疫反应的发展，并促进了在经小肠结肠炎耶尔森氏菌O9肠道感染后迟发型超敏反应（DH）的强烈发展，而对感染小肠结肠炎耶尔森氏菌O3的动物的DH发展没有影响；它还增强了机体的非特异性抵抗力，从而导致感染因子在不同器官和组织中的扩散减少，并随后从体内清除。
