Sánchez F, Hernández G, Rubio M, Santos M, Carretero J, Riesco J, Juanes J, Vázquez R
Department of Human Anatomy and Histology, Faculty of Medicine University of Salamanca, Spain.
Acta Histochem. 1995 Apr;97(2):141-9. doi: 10.1016/S0065-1281(11)80090-5.
The reactions of bilateral adrenalectomy (14 days) on the rat glial fibrillary acidic-immunoreactive elements of the third ventricular ependyma and adjacent neuropil were analyzed using histological, immunohistochemical and morphometric methods. Bilateral adrenalectomy led to a drastic increase in the number of immunoreactive elements located in the neuropil adjacent to the third ventricle and the optic chiasm when compared to normal and sham-operated animals (p < 0.05). By contrast, the adrenalectomized animals receiving corticosterone showed the same characteristics and morphometric values as those found in normal and sham-operated animals. The results show that the participation of the adrenal gland in astroglial responses should be taken into account.
采用组织学、免疫组织化学和形态计量学方法，分析双侧肾上腺切除术（14天）对大鼠第三脑室室管膜及相邻神经毡中胶质纤维酸性蛋白免疫反应性成分的影响。与正常动物和假手术动物相比，双侧肾上腺切除术导致第三脑室和视交叉相邻神经毡中免疫反应性成分的数量急剧增加（p<0.05）。相比之下，接受皮质酮治疗的肾上腺切除动物表现出与正常动物和假手术动物相同的特征和形态计量值。结果表明，应考虑肾上腺在星形胶质细胞反应中的作用。
