[间硝苯地平对老年左心室肥厚大鼠肾和肺细胞膜中二氢吡啶结合位点的影响]
[Effects of m-nifedipine on dihydropyridine binding sites in the cell membranes of kidney and lung from left ventricular hypertrophied elderly rats].
作者信息
Xu Y, Xi T, Rao M R
机构信息
Department of Cardiovascular Pharmacology, Nanjing Medical University.
出版信息
Yao Xue Xue Bao. 1995;30(1):59-62.
Effects of m-nifedipine (m-Nif) on the affinity and density of dihydropyridine (DHP) binding sites in the cell membranes of kidney and lung were investigated using the LVH (left ventricular hypertrophy) induced by Goldblatt (2k-1c) renovascular hypertension in elderly rats. m-Nif markedly reduced blood pressure, left ventricular weight, and decreased the density (Bmax) of DHP binding sites in the cell membranes of kidney and lung from 699 +/- 112, 759 +/- 35 fmol.mg-1 protein to 482 +/- 29, 381 +/- 33 fmol.mg-1 protein. No difference was observed between groups in dissociation constant (KD) values of DHP binding sites. The results suggest that m-Nif could markedly decrease DHP binding sites in the membranes of kidney and lung from cardiac hypertrophied elderly rats.
利用老年大鼠Goldblatt（2k-1c）肾血管性高血压诱导的左心室肥厚（LVH），研究间硝苯地平（m-Nif）对肾和肺细胞膜中二氢吡啶（DHP）结合位点亲和力和密度的影响。m-Nif显著降低血压、左心室重量，并使肾和肺细胞膜中DHP结合位点的密度（Bmax）从699±112、759±35 fmol·mg-1蛋白降至482±29、381±33 fmol·mg-1蛋白。各组间DHP结合位点的解离常数（KD）值未观察到差异。结果表明，m-Nif可显著降低心脏肥厚老年大鼠肾和肺细胞膜中的DHP结合位点。
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