[间硝苯地平与硝苯地平对肾血管性高血压大鼠血流动力学的影响]
[Effects of m-nifedipine and nifedipine on hemodynamics in renovascular hypertensive rats].
作者信息
Yang J R, Xi T, Wu D M, Rao M R
机构信息
Department of Cardiovascular Pharmacology, Nanjing Medical College, China.
出版信息
Zhongguo Yao Li Xue Bao. 1994 May;15(3):260-3.
In the renovascular hypertensive myocardial hypertrophic rats of prevention and regressive groups, the blood pressure was lowered by m-nifedipine (m-Nif) or nifedipine (Nif) of 20 mg.kg-1.d-1, i.g., for 9 wk vs control (LVH) group (P < 0.01). From the isolated working hearts of prevention and regressive groups, it was found that AP, LVSP, +dp/dtmax, -dp/dtmax, CF, and CI values of m-Nif and Nif groups increased higher than that of LVH group, but LVEDP and T was lower in m-Nif and Nif groups. It was concluded that m-Nif exhibits the similar effects like Nif in prevention and reversion of renovascular hypertensive LVH and improvement of hemodynamics.
在预防组和逆转组的肾血管性高血压心肌肥厚大鼠中，以20mg.kg-1.d-1的间硝苯地平（m-Nif）或硝苯地平（Nif）灌胃9周，血压降低，与对照组（左心室肥厚，LVH）相比（P<0.01）。从预防组和逆转组的离体工作心脏发现，m-Nif组和Nif组的主动脉压（AP）、左心室收缩压（LVSP）、左心室内压最大上升速率（+dp/dtmax）、左心室内压最大下降速率（-dp/dtmax）、冠脉流量（CF）和心脏指数（CI）值比LVH组升高更明显，但m-Nif组和Nif组的左心室舒张末压（LVEDP）和张力（T）较低。结论是，m-Nif在预防和逆转肾血管性高血压左心室肥厚及改善血流动力学方面表现出与Nif相似的作用。
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