Jankowski S
Department of Microbiology, Academy of Medicine, Wrocław, Poland.
Acta Microbiol Pol. 1995;44(1):5-14.
The bactericidal action of serum is one of the mechanisms protecting higher organisms from infection by gram-negative bacteria. Complement (C) activation by the classical or alternative pathways plays a main role in this protective action. The bactericidal activity of normal newborn sera against some gram-negative bacteria is less efficient than that of normal adult sera. The reason for this may be connected with the damaged alternative and classical pathways of C activation and with the decreased levels of third -C3 and ninth -C9 factors of C system. A physiological deficiency of IgM antibodies may contribute also to the diminished bactericidal activity of newborn sera. Impaired activity of sera favours the susceptibility of neonates to bactericidal infection.
血清的杀菌作用是高等生物抵御革兰氏阴性菌感染的机制之一。经典途径或替代途径激活补体（C）在这一保护作用中起主要作用。正常新生儿血清对某些革兰氏阴性菌的杀菌活性低于正常成人血清。其原因可能与补体激活的替代途径和经典途径受损以及补体系统第三成分C3和第九成分C9水平降低有关。IgM抗体的生理性缺乏也可能导致新生儿血清杀菌活性降低。血清活性受损会增加新生儿对细菌感染的易感性。
