Nawrot U, Mokracka-Latajka G, Grzybek-Hryncewicz J, Krzyzanowska B, Jankowski S
Department of Microbiology, Medical Academy, Wrocław, Poland.
Acta Microbiol Pol. 1995;44(1):55-61.
The susceptibility od Proteus, Providencia, and Morganella strains to bactericidal action of human serum was examined. The percentage of survival was determined after one and three hours incubation with 50% human serum. The susceptible strains were treated by serum preparations with blocked classical or alternative complement activation pathways as well as with lysozyme removed. Following mechanisms of the bactericidal action of serum were found: complement activated by the classical or alternative pathway with participation of lysozyme, complement activated simultaneously via both pathways-while the participation of lysozyme was necessary for killing some strains and superfluos for others and complement activated only via the classical pathway without lysozyme.
研究了变形杆菌属、普罗威登斯菌属和摩根菌属菌株对人血清杀菌作用的敏感性。将菌株与50%人血清孵育1小时和3小时后，测定其存活百分比。用阻断经典或替代补体激活途径以及去除溶菌酶的血清制剂处理敏感菌株。发现血清杀菌作用的以下机制：经典或替代途径激活的补体并伴有溶菌酶参与；两条途径同时激活的补体——溶菌酶参与对某些菌株的杀伤是必需的，而对另一些菌株则是多余的；仅通过经典途径激活且无溶菌酶参与的补体。
