嘌呤对内皮细胞高能磷酸化合物的影响。

Influence of purines on endothelial high energy phosphates.

作者信息

Griesmacher A, De Abreu R A, Müller M M

机构信息

Dept. of Cardiothoracic Surgery, University Hospital Vienna, Austria.

出版信息

Adv Exp Med Biol. 1994;370:527-30. doi: 10.1007/978-1-4615-2584-4_111.

DOI:10.1007/978-1-4615-2584-4_111

PMID:7660962

Abstract

It was demonstrated that extracellularly available adenosine, which is reported to protect the endothelium during ischaemia and reperfusion [8], is predominantly uptaken and salvaged by HUVECs, thereby enriching the adenine phosphate pool. In this way adenosine could contribute to a regeneration of metabolically disturbed cells via increasing the intracellular ATP. In contrast, all other purines offered can hardly be used by HUVECs to increase the pool of energy rich phosphates.

摘要

已证明，细胞外可利用的腺苷主要被人脐静脉内皮细胞（HUVECs）摄取和挽救，从而丰富腺嘌呤磷酸池，据报道，腺苷在缺血和再灌注过程中可保护内皮[8]。通过这种方式，腺苷可通过增加细胞内三磷酸腺苷（ATP）来促进代谢紊乱细胞的再生。相比之下，HUVECs几乎不能利用提供的所有其他嘌呤来增加富含能量的磷酸盐池。