Nishina S, Azuma N
Department of Ophthalmology, National Children's Hospital, Tokyo, Japan.
Nippon Ganka Gakkai Zasshi. 1995 Jul;99(7):824-8.
The relation between extension of extraretinal vasoproliferation and vitreous fibers in stage 3 mild retinopathy of promaturity was evaluated by light and electron microscopy using 4 eyes obtained after autopsies. Seven developing human eyes from 20 to 40 weeks' gestation were used as controls. At an early stage, when vascular tissues broke the inner limiting membrane of the retina and grew into the vitreous cavity, they extended vertically from the retina. Proliferating extraretinal vessels extended towards the posterior surface of the lens. They ran side by side with the framework of vitreous fibers. Electron microscopy demonstrated multiple attachments between vascular endothelia and vitreous fibers. Normal developing vitreous fibers were very dense and homogeneous, running towards the lens not only from the vitreous base but also from the retina at the equator and at the posterior pole. These findings suggest that extension of extraretinal vasoproliferation in retinopathy of prematurity is induced by the framework of the developing vitreous.
利用4只尸检后获得的眼睛，通过光学显微镜和电子显微镜评估了3期轻度早产儿视网膜病变中视网膜外血管增殖与玻璃体纤维之间的关系。将7只妊娠20至40周的发育中的人眼用作对照。在早期，当血管组织突破视网膜内界膜并长入玻璃体腔时，它们从视网膜垂直延伸。增殖的视网膜外血管向晶状体后表面延伸。它们与玻璃体纤维框架并排排列。电子显微镜显示血管内皮与玻璃体纤维之间有多个附着点。正常发育的玻璃体纤维非常致密且均匀，不仅从玻璃体基底部，而且从赤道和后极的视网膜向晶状体延伸。这些发现表明，早产儿视网膜病变中视网膜外血管增殖的延伸是由发育中的玻璃体框架诱导的。
