Patel B C, Crosset P, Klawans H L
Res Commun Chem Pathol Pharmacol. 1975 Dec;12(4):635-43.
Increased brain gamma-aminobutyric acid (GABA) levels secondary to the administration of sodium valproate failed to inhibit amphetamine-induced stereotyped behavior. This observation raises some doubt as to whether GABA plays a role in the physiology of the striatum and suggests that GABA does not play a role in the pathophysiology of chorea. If this is true, pharmacologic attempts to increase brain GABA may not improve human choreatic disorders.
丙戊酸钠给药后导致脑内γ-氨基丁酸（GABA）水平升高，但未能抑制苯丙胺诱导的刻板行为。这一观察结果对GABA是否在纹状体生理学中起作用提出了一些疑问，并表明GABA在舞蹈病的病理生理学中不起作用。如果这是真的，通过药物手段提高脑内GABA水平可能无法改善人类的舞蹈病障碍。
