猪源大肠杆菌K88ab、K88ac肠道受体：在13号染色体上的区域定位及对K88抗原IgG应答的影响
The porcine intestinal receptor for Escherichia coli K88ab, K88ac: regional localization on chromosome 13 and influence of IgG response to the K88 antigen.
作者信息
Edfors-Lilja I, Gustafsson U, Duval-Iflah Y, Ellergren H, Johansson M, Juneja R K, Marklund L, Andersson L
机构信息
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala.
出版信息
Anim Genet. 1995 Aug;26(4):237-42. doi: 10.1111/j.1365-2052.1995.tb03250.x.
The loci encoding the porcine intestinal receptors for Escherichia coli K88ab and K88ac (K88abR and K88acR) were firmly assigned to chromosome 13 by linkage analysis using a three-generation pedigree. The linear order of these loci and seven other markers on chromosome 13 was determined by multipoint analyses. The K88abR and K88acR loci were tightly linked (theta = 0.01, zeta = 41.06) with the K88abR locus localized 7.4 cM (sex average) proximal to the transferrin locus. The results, together with previous reports from two other groups, provide an unequivocal assignment of the K88 receptor loci to chromosome 13, and reject a previous assignment to chromosome 4. Pigs possessing the receptor had a slightly higher specific IgG response to the K88 antigen after an intramuscular immunization with an E. coli vaccine.
通过使用三代家系进行连锁分析，将编码猪肠道大肠杆菌K88ab和K88ac受体（K88abR和K88acR）的基因座明确地定位到了13号染色体上。通过多点分析确定了这些基因座与13号染色体上其他七个标记的线性顺序。K88abR和K88acR基因座紧密连锁（θ = 0.01，ζ = 41.06），K88abR基因座位于转铁蛋白基因座近端7.4 cM（性别平均）处。这些结果与另外两个研究小组之前的报告一起，明确地将K88受体基因座定位到了13号染色体上，并否定了之前将其定位到4号染色体的说法。在用大肠杆菌疫苗进行肌肉注射免疫后，拥有该受体的猪对K88抗原的特异性IgG反应略高。
Zotero 插件