Peters M H, Sonpal I M, Batra M K
Department of Surgery, Saint Luke's Medical Center, Cleveland, Ohio 44104, USA.
Am Surg. 1995 Sep;61(9):763-6.
The increased risk of developing solid malignant tumors following treatment of Hodgkin's disease has been established in the literature. The association between mantle irradiation for the treatment of Hodgkin's disease and breast carcinoma has only recently been studied in large populations of cured patients. Several factors including age at radiation treatment, the time between treatment and discovery of the cancer, and radiation dosimetry affect the relative risk of the patient for developing breast cancer. Because there appears to be an increased risk of breast cancer in this patient population, a vigilant screening routine should be initiated, and aggressive operative therapy should be considered.
霍奇金病治疗后发生实体恶性肿瘤的风险增加已在文献中得到证实。仅在最近才对大量治愈患者群体研究了用于治疗霍奇金病的斗篷野照射与乳腺癌之间的关联。包括放疗时的年龄、治疗与癌症发现之间的时间以及放射剂量测定在内的几个因素会影响患者患乳腺癌的相对风险。由于该患者群体中似乎存在乳腺癌风险增加的情况，应启动严格的筛查程序，并考虑积极的手术治疗。
