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皮肤淋巴增生性疾病中p53癌蛋白的表达

p53 oncoprotein expression in cutaneous lymphoproliferations.

作者信息

Beylot-Barry M, Vergier B, DeMascarel A, Beylot C, Merlio J P

机构信息

Service de Dermatologie, Centre Hospitalo-Universitaire de Bordeaux (France).

出版信息

Arch Dermatol. 1995 Sep;131(9):1019-24.

PMID:7661603
Abstract

BACKGROUND AND DESIGN

p53 overexpression has been reported in systemic lymphoproliferations, but our study is the first large series, to our knowledge, dealing with p53 expression in primary cutaneous lymphomas. p53 immunohistochemical detection using DO7 monoclonal antibody was performed in 54 cutaneous lymphoproliferative disorders, including 37 primary cutaneous T- or B-cell lymphomas.

RESULTS

No expression of p53 was found in 14 mycosis fungoides and seven pleomorphic T-cell lymphomas of either low or high grade of malignancy. Furthermore, no p53-positive cells were shown in low-grade B-cell lymphomas and in benign chronic dermatoses. p53 overexpression was seen over lymphomatous cells in 10 cutaneous lymphomas of high grade of T- or B-cell origin with two immunoblastic, three centroblastic, and five anaplastic lymphomas. Five of them occurred in human immunodeficiency virus-infected individuals, suggesting a possible interaction between p53 and viral proteins. p53 immunoreactivity was found over Reed-Sternberg-like cells in two cases of lymphomatoid papulosis. A labeling of keratinocytes located mainly in basal cell layers of the epidermis was observed in only five cases regardless of the lymphoma histologic subtype.

CONCLUSIONS

p53 overexpression was not found in the most frequent primary cutaneous lymphomas, epidermotropic T-cell lymphomas. Alternatively, p53 immunoreactivity was observed in most primary cutaneous lymphomas of high grade of malignancy occurring in individuals either infected or not infected by human immunodeficiency virus. Molecular studies will determine if p53 overexpression is associated with p53 gene alteration and help to understand the role of p53 in primary cutaneous lymphoma genesis.

摘要

背景与设计

已有报道称p53在系统性淋巴细胞增殖性疾病中过表达,但据我们所知,我们的研究是首个关于原发性皮肤淋巴瘤中p53表达的大型系列研究。使用DO7单克隆抗体对54例皮肤淋巴细胞增殖性疾病进行了p53免疫组化检测,其中包括37例原发性皮肤T或B细胞淋巴瘤。

结果

在14例蕈样肉芽肿和7例低级别或高级别恶性多形性T细胞淋巴瘤中未发现p53表达。此外,在低级别B细胞淋巴瘤和良性慢性皮肤病中也未显示p53阳性细胞。在10例高级别T或B细胞起源的皮肤淋巴瘤中,包括2例免疫母细胞性、3例中心母细胞性和5例间变性淋巴瘤,淋巴瘤细胞中可见p53过表达。其中5例发生在人类免疫缺陷病毒感染个体中,提示p53与病毒蛋白之间可能存在相互作用。在2例淋巴瘤样丘疹病中,在里德-施特恩伯格样细胞上发现了p53免疫反应性。无论淋巴瘤组织学亚型如何,仅在5例中观察到主要位于表皮基底细胞层的角质形成细胞有标记。

结论

在最常见的原发性皮肤淋巴瘤——亲表皮性T细胞淋巴瘤中未发现p53过表达。相反,在人类免疫缺陷病毒感染或未感染个体中发生的大多数高级别原发性皮肤淋巴瘤中观察到了p53免疫反应性。分子研究将确定p53过表达是否与p53基因改变相关,并有助于了解p53在原发性皮肤淋巴瘤发生中的作用。

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