Resnik K S, Kantor G R, Lessin S R, Kadin M E, Chooback L, Cooper H S, Vonderheid E C
Department of Dermatology, Medical College of Pennsylvania, Philadelphia, USA.
Arch Dermatol. 1995 Sep;131(9):1052-6.
Mycosis fungoides primarily localized to the palms and soles is rare and has been previously reported as cutaneous lymphoma in four patients or as Woringer-Kolopp disease in eight patients.
Four patients were initially diagnosed and treated unsuccessfully for various palmoplantar dermatitides until histopathologic findings revealed mycosis fungoides. Each case exhibited a clonal rearrangement of T-cell receptor gamma genes and immunohistochemical studies consonant with mycosis fungoides. All patients had limited skin involvement without evidence of extracutaneous involvement.
Mycosis fungoides palmaris et plantaris is an uncommon expression of mycosis fungoides that manifests primarily on the palms and soles and clinically may mimic various inflammatory palmoplantar dermatoses. A biopsy is recommended in the evaluation of recalcitrant palmoplantar dermatoses.
主要局限于手掌和足底的蕈样肉芽肿较为罕见，此前曾有4例患者被报道为皮肤淋巴瘤，8例患者被报道为沃林格-科洛普病。
4例患者最初因各种掌跖性皮炎被诊断并接受治疗，但均未成功，直到组织病理学检查结果显示为蕈样肉芽肿。每例病例均表现出T细胞受体γ基因的克隆重排，免疫组织化学研究结果与蕈样肉芽肿一致。所有患者皮肤受累局限，无皮肤外受累证据。
掌跖蕈样肉芽肿是蕈样肉芽肿的一种不常见表现形式，主要表现在手掌和足底，临床上可能类似各种炎症性掌跖皮肤病。对于难治性掌跖皮肤病的评估，建议进行活检。
