Floersheim G L
Schweiz Med Wochenschr. 1975 Oct 25;105(43):1373-81.
The pharmacological alteration of immunological reactivity is considered. The immunosuppressive drugs may be classified according to their chemical class and their antigen- or cycle-dependency. A relative specificity towards the lymphoid system is cyclophosphamide. New vistas are opened by the modulation of immunological reactivity by cyclic nucleotides. The possibilities afforded by the combined use of immunosuppressive drugs have not been fully exploited. A short therapeutic program including donor antigen, procarbazine and antilymphocyte serum induces immunological tolerance to allogeneic skin grafts in mice and bone marrow allografts in dogs. Immunosuppressive properties of microorganisms are exemplified.
考虑免疫反应性的药理学改变。免疫抑制药物可根据其化学类别以及抗原依赖性或周期依赖性进行分类。环磷酰胺对淋巴系统具有相对特异性。环核苷酸对免疫反应性的调节开辟了新的前景。免疫抑制药物联合使用所提供的可能性尚未得到充分利用。一个包含供体抗原、丙卡巴肼和抗淋巴细胞血清的短期治疗方案可诱导小鼠对同种异体皮肤移植以及犬对同种异体骨髓移植产生免疫耐受。文中举例说明了微生物的免疫抑制特性。
