Stauber R E, Stepan V, Trauner M, Wilders-Truschnig M, Leb G, Krejs G J
Department of Medicine, Karl Franzens University, Graz, Austria.
Alcohol Alcohol. 1995 Mar;30(2):171-6.
The determination of carbohydrate-deficient transferrin (CDT) in serum has been suggested as a marker of alcohol abuse. We evaluated serum CDT in 199 patients admitted to our Department of Medicine using a commercially available radioimmunoassay kit for CDT. A history of alcohol consumption was obtained quantitatively by a self-administered questionnaire and qualitatively by the Munich Alcoholism Test. Using a cut-off level of 60 g ethanol per day according to the information from the questionnaire. CDT had a sensitivity of 70% and a specificity of 84%. False-positive values were primarily encountered in cases of hepatic malignoma, primary biliary cirrhosis and chronic hepatitis C. The sensitivity and specificity of CDT was superior to two other markers of chronic ethanol consumption, serum gamma-glutamyltransferase and mean cell volume, and thus proved to be the best single laboratory test for the detection of alcohol abuse.
血清中缺糖转铁蛋白（CDT）的测定已被提议作为酒精滥用的一项标志物。我们使用一种市售的CDT放射免疫分析试剂盒，对收入我们内科的199例患者的血清CDT进行了评估。通过一份自我填写的问卷对饮酒史进行定量获取，并通过慕尼黑酒精中毒测试进行定性评估。根据问卷信息，以每天60克乙醇作为临界值，CDT的灵敏度为70%，特异性为84%。假阳性值主要出现在肝恶性肿瘤、原发性胆汁性肝硬化和丙型慢性肝炎病例中。CDT的灵敏度和特异性优于另外两项慢性乙醇摄入标志物，即血清γ-谷氨酰转移酶和平均细胞体积，因此被证明是检测酒精滥用的最佳单一实验室检测方法。
