Lin W C, Desiderio S
Dept of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Immunol Today. 1995 Jun;16(6):279-89. doi: 10.1016/0167-5699(95)80182-0.
V(D)J recombination is a major source of antigen receptor diversity and represents the only known form of site-specific DNA rearrangement in vertebrates. V(D)J recombination is initiated by specific DNA cleavage at recombinational signal sequences and requires components of the general machinery used for double-strand (DS)-break repair. The involvement of DS cleavage and repair mechanisms suggests that V(D)J recombination might be coupled to the cell cycle, as introduction or persistence of DS breaks during DNA replication or mitosis could interfere with faithful transmission of genetic information to daughter cells. Here, Weei-Chin Lin and Stephen Desiderio review recent evidence indicating that this is indeed the case and consider some biological implications of this linkage.
V(D)J重组是抗原受体多样性的主要来源，也是脊椎动物中已知的唯一一种位点特异性DNA重排形式。V(D)J重组由重组信号序列处的特异性DNA切割引发，并需要用于双链（DS）断裂修复的通用机制的组成部分。DS切割和修复机制的参与表明V(D)J重组可能与细胞周期相关，因为在DNA复制或有丝分裂期间DS断裂的引入或持续存在可能会干扰遗传信息向子细胞的准确传递。在这里，林伟钦和斯蒂芬·德西德里奥回顾了最近的证据，表明情况确实如此，并探讨了这种联系的一些生物学意义。
