Herzog Sebastian, Reth Michael, Jumaa Hassan
Centre for Biological Signalling Studies, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany.
Nat Rev Immunol. 2009 Mar;9(3):195-205. doi: 10.1038/nri2491.
The pre-B-cell receptor (pre-BCR) is expressed following the productive recombination of the immunoglobulin heavy chain gene. Signals through the pre-BCR are required for initiating diverse processes in pre-B cells, including proliferation and recombination of the light chain gene, which eventually lead to the differentiation of pre-B cells to immature B cells. However, the molecular mechanisms by which the pre-BCR promotes these processes remain largely unresolved. Recent findings suggest that forkhead box O (FOXO) transcription factors connect pre-BCR signalling to the activation of the recombination machinery. In this Review, we discuss how FOXO transcription factors are regulated by the pre-BCR to allow the progression of the cell cycle and the recombination of the light chain gene.
前B细胞受体（pre-BCR）在免疫球蛋白重链基因发生有效重排后表达。前B细胞中启动多种过程需要通过前B细胞受体发出信号，这些过程包括轻链基因的增殖和重排，最终导致前B细胞分化为未成熟B细胞。然而，前B细胞受体促进这些过程的分子机制在很大程度上仍未得到解决。最近的研究结果表明，叉头框O（FOXO）转录因子将前B细胞受体信号传导与重组机制的激活联系起来。在本综述中，我们讨论了FOXO转录因子如何受前B细胞受体调控，以促进细胞周期进程和轻链基因的重排。
