Ribet M, Dambron P
University of Lille, France.
Eur J Cardiothorac Surg. 1995;9(5):231-6. doi: 10.1016/s1010-7940(05)80155-1.
Seventy-five cases of multiple primary lung cancers, representing 3.78% of a series of 1980 consecutively resected tumors, were divided into 24 synchronous and 51 metachronous cancers, according to the criteria of Martini and Melamed. They all concerned tobacco-smoking men. The synchronous tumors were symptomatic in 66% of the cases, the metachronous tumors in 37%. Nine synchronous locations were unilateral and 15 were bilateral; 20 metachronous locations were ipsilateral and 31 were contralateral. There were three third metachronous cancers. The resection of both tumours was performed for 15 synchronous cancers and for 19 metachronous cancers, including two third metachronous tumors. There were two deaths related to metachronous cancers. No patient with resected synchronous cancers survived 5 years, while 20% of patients with resected metachronous cancers survived this period. Synchronous cancers appear to represent an advanced stage. Metachronous cancers are often diagnosed too late.
75例多原发性肺癌占1980例连续切除肿瘤的3.78%，根据Martini和Melamed的标准分为24例同时性癌和51例异时性癌。所有病例均为吸烟男性。66%的同时性肿瘤有症状，37%的异时性肿瘤有症状。9个同时性肿瘤位于单侧，15个位于双侧；20个异时性肿瘤位于同侧，31个位于对侧。有3例第三次异时性癌。15例同时性癌和19例异时性癌（包括2例第三次异时性肿瘤）进行了双肿瘤切除。有2例死亡与异时性癌有关。切除的同时性癌患者无1例存活5年，而异时性癌切除患者有20%存活了这一时期。同时性癌似乎代表晚期。异时性癌往往诊断过晚。
