Raz N, Torres I J, Acker J D
Department of Psychology, University of Memphis, Tennessee 38152, USA.
Neurobiol Learn Mem. 1995 Mar;63(2):133-42. doi: 10.1006/nlme.1995.1013.
We reviewed postmortem and neuroimaging studies of striatal neuroanatomy in humans. The quantitative review revealed evidence of moderate age-related shrinkage of the caudate nucleus and the putamen and consistent leftward asymmetry of the globus pallidus. The data on sex differences were very sparse. We examined neostriatal structures in two samples (healthy volunteers and patients with negative radiological findings) using in vivo magnetic resonance imaging. In both samples, bilateral age-related shrinkage of the caudate nucleus was found, although among the patients the effect was significant only for males. The putamen was measured only in the second sample, and age-related reduction in its volume was found also only among males. A trend for rightward asymmetry in the volume of caudate nucleus was observed in both samples, although it reached statistical significance only among the patients. Putative pathological and physiological mechanisms underlying the observed differences in teh neostriatum are discussed.
我们回顾了人类纹状体神经解剖学的尸检和神经影像学研究。定量分析显示，有证据表明尾状核和壳核存在与年龄相关的中度萎缩，以及苍白球持续的左侧不对称。关于性别差异的数据非常稀少。我们使用活体磁共振成像检查了两个样本（健康志愿者和放射学检查结果为阴性的患者）中的新纹状体结构。在两个样本中均发现尾状核存在双侧与年龄相关的萎缩，不过在患者中，这种影响仅在男性中显著。仅在第二个样本中测量了壳核，其体积与年龄相关的减小也仅在男性中发现。在两个样本中均观察到尾状核体积存在向右不对称的趋势，不过仅在患者中达到统计学显著水平。文中讨论了新纹状体中观察到的差异背后可能的病理和生理机制。
