O'Sullivan R L, Rauch S L, Breiter H C, Grachev I D, Baer L, Kennedy D N, Keuthen N J, Savage C R, Manzo P A, Caviness V S, Jenike M A
Department of Psychiatry, Massachusetts General Hospital, Charlestown, USA.
Biol Psychiatry. 1997 Jul 1;42(1):39-45. doi: 10.1016/S0006-3223(96)00297-1.
A morphometric magnetic resonance imaging (MRI) study compared volumes of brain structures in 10 female subjects with trichotillomania (repetitive hair-pulling) versus 10 normal controls matched for sex, age, handedness, and education. Three-dimensional MRI scans were blindly normalized and segmented using well-characterized semiautomated intensity and differential contour algorithms by signal intensity-frequency histograms. Consistent with one a priori hypothesis, left putamen volume was found to be significantly smaller in trichotillomania subjects as compared with normal matched controls. This is the first report of a structural brain abnormality in trichotillomania. Results are discussed in terms of putative relationships between trichotillomania, Tourette's syndrome, and obsessive-compulsive disorder.
一项形态测量磁共振成像（MRI）研究比较了10名患拔毛癖（反复拔毛）的女性受试者与10名在性别、年龄、利手和教育程度上相匹配的正常对照者的脑结构体积。通过信号强度-频率直方图，使用特征明确的半自动强度和差分轮廓算法对三维MRI扫描进行盲目归一化和分割。与一个先验假设一致，发现拔毛癖受试者的左侧壳核体积与正常匹配对照者相比明显更小。这是关于拔毛癖脑结构异常的首次报告。根据拔毛癖、图雷特综合征和强迫症之间的假定关系对结果进行了讨论。
