急性淋巴细胞白血病患儿淋巴细胞上白细胞介素2受体和CD45RO抗原的表达在巨细胞病毒和水痘-带状疱疹病毒刺激下受损。
Impaired expression of interleukin 2 receptor and CD45RO antigen on lymphocytes from children with acute lymphoblastic leukemia in response to cytomegalovirus and varicella-zoster virus.
作者信息
Mizutani K, Ito M, Nakano T, Kamiya H, Sakurai M
机构信息
Department of Pediatrics, Mie University School of Medicine, Japan.
出版信息
Clin Diagn Lab Immunol. 1995 May;2(3):381-4. doi: 10.1128/cdli.2.3.381-384.1995.
Abstract
The expression of CD25 and CD45RO in lymphocytes from patients with acute lymphoblastic leukemia in response to cytomegalovirus and varicella-zoster virus antigens was analyzed by flow cytometry. It is suggested that the defects in the immune response to cytomegalovirus and varicella-zoster virus in patients with acute lymphoblastic leukemia on chemotherapy are in the expression of CD25 and in the switching of CD45RA cells to CD45RO cells.
摘要
通过流式细胞术分析急性淋巴细胞白血病患者淋巴细胞中CD25和CD45RO对巨细胞病毒和水痘-带状疱疹病毒抗原的反应表达。提示化疗的急性淋巴细胞白血病患者对巨细胞病毒和水痘-带状疱疹病毒免疫反应的缺陷在于CD25的表达以及CD45RA细胞向CD45RO细胞的转换。
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