Gershon A A, LaRussa P, Steinberg S, Mervish N, Lo S H, Meier P
Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
J Infect Dis. 1996 Feb;173(2):450-3. doi: 10.1093/infdis/173.2.450.
Whether reexposure of varicella-immune persons to varicella-zoster virus would protect against or predispose to development of zoster was analyzed. The rate of zoster in 511 leukemic recipients of varicella vaccine who had 1 or > 1 dose of varicella vaccine and in those who did or did not have a household exposure to varicella was determined. A Kaplan-Meier life-table analysis revealed that the incidence of zoster was lower in those given > 1 dose of vaccine (P < .05). A Cox proportional hazards analysis showed that both household exposure to varicella and receipt of > 1 dose of vaccine were highly protective (P < .01) against zoster. Thus, the risk of zoster is decreased by reexposure to varicella-zoster virus, either by vaccination or by close exposure to varicella.
分析了水痘免疫者再次接触水痘-带状疱疹病毒是否能预防或易引发带状疱疹。确定了511名接受过1剂或超过1剂水痘疫苗的白血病患者以及那些有或没有家庭内水痘暴露史的患者中带状疱疹的发生率。卡普兰-迈耶生存表分析显示，接种超过1剂疫苗的患者带状疱疹发病率较低（P < .05）。Cox比例风险分析表明，家庭内水痘暴露和接种超过1剂疫苗对带状疱疹都有高度保护作用（P < .01）。因此，通过接种疫苗或密切接触水痘再次接触水痘-带状疱疹病毒可降低带状疱疹风险。
