一名多发性骨髓瘤患者出现伯基特易位（8；22）（q24；q11）

Burkitt translocation (8;22)(q24;q11) in a patient with multiple myeloma.

作者信息

Look R M, Lim S W, Schreck R R, Lee S, Fuerst M P, Lawrence G N, Kusuanco D A, Kessler C E, Giles F J

机构信息

Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

出版信息

Cancer Genet Cytogenet. 1995 Jul 15;82(2):100-2. doi: 10.1016/0165-4608(95)00049-u.

DOI:10.1016/0165-4608(95)00049-u

PMID:7664237

Abstract

The prevalence of chromosomal abnormalities in multiple myeloma (MM) has been difficult to detect by karyotyping primarily because of the low proliferative rate of malignant plasma cells. The reported incidences of abnormal karyotypes range from 24% to 63% in bone marrows obtained from MM patients, with the higher rates being seen in aggressive disease [1-8]. Detection of abnormal karyotypes in MM has been associated with a poor prognosis. We report a MM patient with an 8;22 Burkitt translocation, the first such reported case.

摘要

多发性骨髓瘤（MM）中染色体异常的发生率通过核型分析一直难以检测到，主要是因为恶性浆细胞的增殖率较低。在MM患者的骨髓中，报道的异常核型发生率在24%至63%之间，侵袭性疾病中发生率更高[1-8]。MM中异常核型的检测与预后不良相关。我们报告了一例患有8;22伯基特易位的MM患者，这是首例此类报道的病例。