与淀粉样变性和t(1;20)(q21;q11)易位相关的多发性骨髓瘤。
Multiple myeloma associated with amyloidosis and t(1;20)(q21;q11) translocation.
作者信息
Otokida K, Yoshida H, Mizunuma Y, Yamada M, Hiramori K
机构信息
Second Department of Internal Medicine, Iwate Medical University School of Medicine, Morioka.
出版信息
Tohoku J Exp Med. 1990 Dec;162(4):363-5. doi: 10.1620/tjem.162.363.
A 59-year-old woman with nephrotic syndrome was diagnosed as having primary amyloidosis based on the detection of amyloid deposition (AL-protein) in the esophagus and kidneys. Bone marrow aspirate showed plasmocytic proliferation, leading to a diagnosis of multiple myeloma (IgG lambda-type). In addition, a very rare translocation t(1; 20) (q21; q11) was seen by chromosomal analysis of both the bone marrow and peripheral blood.
一名59岁肾病综合征女性，基于在食管和肾脏中检测到淀粉样蛋白沉积（AL蛋白），被诊断为原发性淀粉样变性。骨髓穿刺显示浆细胞增殖，从而诊断为多发性骨髓瘤（IgG λ型）。此外，通过对骨髓和外周血进行染色体分析，发现了一种非常罕见的易位t(1; 20)(q21; q11)。
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