Ryberg D, Lindstedt B A, Zienolddiny S, Haugen A
Department of Toxicology, National Institute of Occupational Health, Oslo, Norway.
Cancer Res. 1995 Sep 15;55(18):3996-9.
Alterations in 5 microsatellite loci were analyzed in tumors from 137 patients with primary non-small cell lung carcinomas that were also genotyped for the Hras1 variable number of tandem repeats (VNTR) locus. Twenty-nine patients (21%) had changes in at least one microsatellite locus. A majority of these cases (24 of 29, 83%) had VNTR alleles classified as rare in the population. The frequency of these rare alleles were significantly higher among lung cancer patients than in healthy controls (P = 0.016 or 1.80; 95% confidence interval = 1.13-2.85). Microsatellite alterations were significantly more frequent among patients with at least one rare Hras1 VNTR allele (24 of 40, 60%) compared to patients with two common alleles (5 of 97, 5%; P < 0.001 or 27.6; 95% confidence interval = 8.18-82.9). Microsatellite alterations were also more frequent among patients below 50 years of age (8 of 21, 38%) than for older patients (21 of 112, 19%).
对137例原发性非小细胞肺癌患者肿瘤中的5个微卫星位点改变进行了分析，这些患者还对Hras1可变串联重复序列（VNTR）位点进行了基因分型。29例患者（21%）至少有一个微卫星位点发生改变。这些病例中的大多数（29例中的24例，83%）具有在人群中被归类为罕见的VNTR等位基因。这些罕见等位基因在肺癌患者中的频率显著高于健康对照（P = 0.016或1.80；95%置信区间 = 1.13 - 2.85）。与具有两个常见等位基因的患者（97例中的5例，5%）相比，至少有一个罕见Hras1 VNTR等位基因的患者中微卫星改变明显更频繁（40例中的24例，60%；P < 0.001或27.6；95%置信区间 = 8.18 - 82.9）。50岁以下患者中微卫星改变也比老年患者更频繁（21例中的8例，38%对比112例中的21例，19%）。
