• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Genomic structure of the human TATA-box-binding protein (TBP).

作者信息

Chalut C, Gallois Y, Poterszman A, Moncollin V, Egly J M

机构信息

Institute de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, C.U. de Strasbourg, France.

出版信息

Gene. 1995 Aug 19;161(2):277-82. doi: 10.1016/0378-1119(95)00209-o.

DOI:10.1016/0378-1119(95)00209-o
PMID:7665093
Abstract

The gene encoding the human TATA-box-binding protein (hTBP) is contained within a 20-kb DNA fragment and is split into eight exons. The coding sequence is interrupted by six introns and the 5'-untranslated region (5'-UTR) of the gene by a 2.5-kb intron. A comparison of the hTBP exon/intron organization with the various TBP cloned to date is presented.

摘要

相似文献

1
Genomic structure of the human TATA-box-binding protein (TBP).
Gene. 1995 Aug 19;161(2):277-82. doi: 10.1016/0378-1119(95)00209-o.
2
Structures of genes encoding TATA box-binding proteins from Trimeresurus gramineus and T. flavoviridis snakes.
Gene. 1995 Jan 23;152(2):209-13. doi: 10.1016/0378-1119(94)00681-h.
3
Analysis of the chicken TBP-like protein(tlp) gene: evidence for a striking conservation of vertebrate TLPs and for a close relationship between vertebrate tbp and tlp genes.鸡类TBP样蛋白（tlp）基因分析：脊椎动物TLP显著保守以及脊椎动物tbp与tlp基因密切关系的证据
Nucleic Acids Res. 1999 Aug 1;27(15):3146-52. doi: 10.1093/nar/27.15.3146.
4
The TATA-box-binding protein (TBP) of Halobacterium salinarum. Cloning of the tbp gene, heterologous production of TBP and folding of TBP into a native conformation.盐生盐杆菌的TATA盒结合蛋白（TBP）。tbp基因的克隆、TBP的异源表达及TBP折叠成天然构象。
Eur J Biochem. 1997 Oct 1;249(1):318-24. doi: 10.1111/j.1432-1033.1997.t01-1-00318.x.
5
Crystal structure of a human TATA box-binding protein/TATA element complex.人TATA盒结合蛋白/TATA元件复合物的晶体结构
Proc Natl Acad Sci U S A. 1996 May 14;93(10):4862-7. doi: 10.1073/pnas.93.10.4862.
6
Promoter structure of the mouse TATA-binding protein (TBP) gene.
Biochem Biophys Res Commun. 1996 Aug 5;225(1):275-80. doi: 10.1006/bbrc.1996.1166.
7
TATA element recognition by the TATA box-binding protein has been conserved throughout evolution.TATA框结合蛋白对TATA元件的识别在整个进化过程中一直保守。
Genes Dev. 1999 Dec 15;13(24):3217-30. doi: 10.1101/gad.13.24.3217.
8
Isolation and characterization of the gene coding for Artemia franciscana TATA-binding protein: expression in cryptobiotic and developing embryos.
Biochim Biophys Acta. 1999 Jun 9;1445(3):271-82. doi: 10.1016/s0167-4781(99)00052-4.
9
Exon 4-encoded acidic domain in the epithelium-restricted Ets factor, ESX, confers potent transactivating capacity and binds to TATA-binding protein (TBP).上皮细胞特异性Ets因子ESX中由外显子4编码的酸性结构域具有强大的反式激活能力，并能与TATA结合蛋白（TBP）结合。
Oncogene. 1999 Jun 24;18(25):3682-95. doi: 10.1038/sj.onc.1202674.
10
Solution structure of a TBP-TAF(II)230 complex: protein mimicry of the minor groove surface of the TATA box unwound by TBP.TBP-TAF（II）230复合物的溶液结构：TBP解开的TATA盒小沟表面的蛋白质模拟。
Cell. 1998 Sep 4;94(5):573-83. doi: 10.1016/s0092-8674(00)81599-8.

引用本文的文献

1
Molecular Mechanisms of Spinocerebellar Ataxia Type 17.17型脊髓小脑共济失调的分子机制
Mol Neurobiol. 2025 May;62(5):5720-5729. doi: 10.1007/s12035-024-04645-z. Epub 2024 Nov 30.
2
Taenia solium TAF6 and TAF9 bind to a downstream promoter element present in the Tstbp1 gene core promoter.猪带绦虫 TAF6 和 TAF9 结合到 Tstbp1 基因核心启动子中存在的下游启动子元件。
PLoS One. 2024 Aug 29;19(8):e0306633. doi: 10.1371/journal.pone.0306633. eCollection 2024.
3
A kinetic model of TBP auto-regulation exhibits bistability.TBP 自动调控的动力学模型表现出双稳性。
Biol Direct. 2010 Aug 5;5:50. doi: 10.1186/1745-6150-5-50.
4
Heterozygous disruption of the TATA-binding protein gene in DT40 cells causes reduced cdc25B phosphatase expression and delayed mitosis.DT40细胞中TATA结合蛋白基因的杂合性破坏导致细胞周期蛋白依赖性激酶25B（cdc25B）磷酸酶表达降低和有丝分裂延迟。
Mol Cell Biol. 2001 Apr;21(7):2435-48. doi: 10.1128/MCB.21.7.2435-2448.2001.
5
Analysis of the chicken TBP-like protein(tlp) gene: evidence for a striking conservation of vertebrate TLPs and for a close relationship between vertebrate tbp and tlp genes.鸡类TBP样蛋白（tlp）基因分析：脊椎动物TLP显著保守以及脊椎动物tbp与tlp基因密切关系的证据
Nucleic Acids Res. 1999 Aug 1;27(15):3146-52. doi: 10.1093/nar/27.15.3146.
6
Biochemical and genetic characterization of the dominant positive element driving transcription ofthe yeast TBP-encoding gene, SPT15.驱动酵母TBP编码基因SPT15转录的显性正调控元件的生化与遗传学特征分析
Nucleic Acids Res. 1998 Sep 15;26(18):4186-95. doi: 10.1093/nar/26.18.4186.
7
Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH.转录/DNA修复因子TFIIH核心的第五个亚基p52的克隆与特性分析
EMBO J. 1997 Mar 3;16(5):1093-102. doi: 10.1093/emboj/16.5.1093.