大肠杆菌RNA聚合酶α亚基的C末端区域是FlhD/FlhC复合物对鞭毛二级操纵子进行转录激活所必需的。
The C-terminal region of the alpha subunit of Escherichia coli RNA polymerase is required for transcriptional activation of the flagellar level II operons by the FlhD/FlhC complex.
作者信息
Liu X, Fujita N, Ishihama A, Matsumura P
机构信息
Department of Microbiology and Immunology, University of Illinois at Chicago 60612-7344, USA.
出版信息
J Bacteriol. 1995 Sep;177(17):5186-8. doi: 10.1128/jb.177.17.5186-5188.1995.
Abstract
A number of transcription activators have been found to activate transcription via protein-protein contact between RNA polymerase alpha subunits and transcription factors; they are classified as class I factors. In this report, we demonstrate that the FlhD/FlhC complex, a transcription activator of the Escherichia coli flagellar regulon, requires the C-terminal domain of the RNA polymerase alpha subunit for transcription activation. We conclude that FlhD/FlhC is a class I transcription factor.
摘要
已发现许多转录激活因子通过RNA聚合酶α亚基与转录因子之间的蛋白质-蛋白质接触来激活转录；它们被归类为I类因子。在本报告中，我们证明了FlhD/FlhC复合物（大肠杆菌鞭毛调节子的转录激活因子）需要RNA聚合酶α亚基的C末端结构域来激活转录。我们得出结论，FlhD/FlhC是一种I类转录因子。
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