Friedman R A, Markowitz J C, Parides M, Kocsis J H
New York Hospital, Cornell Medical Center, NY 10021, USA.
J Affect Disord. 1995 May 17;34(2):85-8. doi: 10.1016/0165-0327(95)00003-6.
Despite some evidence that short-term antidepressant treatment improves social dysfunction in depressed patients, little is known about the response of specific social impairments in dysthymic patients to antidepressant medication. We examined the effect of acute (10 weeks), open-label desipramine (DMI) treatment on social functioning in subjects with DSM-III-R dysthymia. Social functioning was assessed with the social adjustment scale self-report (SAS-SR) at baseline and at week 10. Compared with DMI nonresponders DMI responders showed significantly greater improvement in overall social functioning (F2,45 = 5.46, P < 0.0001) and in enjoyment of leisure time (F2,45 = 14.38, P < 0.0001) on the SAS-SR. Dysthymic patients who respond to DMI improve significantly in social functioning. Diminished capacity to enjoy leisure time may be a state marker of depression in some chronically depressed patients.
尽管有证据表明短期抗抑郁治疗可改善抑郁症患者的社会功能障碍，但对于恶劣心境障碍患者特定社会功能损害对抗抑郁药物的反应却知之甚少。我们研究了急性（10周）、开放标签的去甲丙咪嗪（DMI）治疗对符合DSM-III-R恶劣心境障碍标准的受试者社会功能的影响。在基线和第10周时，使用社会适应量表自我报告（SAS-SR）评估社会功能。与DMI无反应者相比，DMI反应者在SAS-SR上的总体社会功能（F2,45 = 5.46，P < 0.0001）和休闲时间享受方面（F2,45 = 14.38，P < 0.0001）有显著更大的改善。对DMI有反应的恶劣心境障碍患者在社会功能方面有显著改善。在一些慢性抑郁症患者中，享受休闲时间能力的下降可能是抑郁的一种状态标志。
