Markowitz J C, Friedman R A, Miller N, Spielman L A, Moran M E, Kocsis J H
Cornell University Medical College, New York, NY 10021, USA.
J Affect Disord. 1996 Nov 4;41(1):59-62. doi: 10.1016/0165-0327(96)00067-5.
Interpersonal difficulties of dysthymic patients are little studied. We used the Inventory of Interpersonal Problems (IIP) to assess baseline status and medication response in chronic depression.
39 chronically depressed subjects answered the IIP at entry and after 10 weeks of desipramine (DMI). Seventeen DMI responders completed IIPs after a 16-week continuation phase.
Mean scores improved on all six IIP subscales during acute treatment. Continuation phase IIP improved non-significantly, approaching normative scores. Baseline IIP score correlated inversely with treatment outcome.
Findings replicate in greater interpersonal detail research demonstrating rapid social amelioration in chronically depressed responders to antidepressant medication. The IIP may be useful as a predictive and interpersonal sensitivity measure in treatment studies of chronic depression.
心境恶劣障碍患者的人际困难鲜有研究。我们使用人际问题量表（IIP）来评估慢性抑郁症患者的基线状态及药物反应。
39名慢性抑郁症患者在入组时及接受去甲丙咪嗪（DMI）治疗10周后填写IIP。17名DMI有效者在16周的维持治疗阶段后完成IIP。
在急性治疗期间，IIP所有六个分量表的平均分均有所改善。维持治疗阶段IIP有改善但不显著，接近常模分数。基线IIP分数与治疗结果呈负相关。
研究结果在更详细的人际研究中得到重复，表明对抗抑郁药物有反应的慢性抑郁症患者的社交状况迅速改善。IIP在慢性抑郁症治疗研究中可用作预测指标及人际敏感性测量工具。
