Loncar D, Singer S J
Department of Biology, University of California, San Diego, La Jolla 92093-0322, USA.
Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8154-7. doi: 10.1073/pnas.92.18.8154.
At an early stage in embryogenesis, the Drosophila blastoderm is a syncytium in which approximately 6000 nuclei align under the plasma membrane. During the interphase of nuclear cycle 14, a wave of membrane formation descends from the blastoderm surface to enclose each nucleus in an intact cell membrane. We show by immunofluorescence microscopy that the membrane-formation process is closely accompanied in space and time by a wave of tyrosine phosphorylation, suggesting that one or more tyrosine kinases and phosphatases are active in the process.
在胚胎发生的早期阶段，果蝇胚盘是一个合胞体，其中约6000个细胞核排列在质膜下方。在核周期14的间期，一波膜形成过程从胚盘表面向下延伸，将每个细胞核包裹在完整的细胞膜中。我们通过免疫荧光显微镜观察发现，膜形成过程在空间和时间上都紧密伴随着一波酪氨酸磷酸化，这表明在该过程中有一个或多个酪氨酸激酶和磷酸酶处于活跃状态。
