关于维生素E醌抗凝血作用的机制。
On the mechanism of the anticlotting action of vitamin E quinone.
作者信息
Dowd P, Zheng Z B
机构信息
Department of Chemistry, University of Pittsburgh, PA 15260, USA.
出版信息
Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8171-5. doi: 10.1073/pnas.92.18.8171.
Abstract
Vitamin E in the reduced, alpha-tocopherol form shows very modest anticlotting activity. By contrast, vitamin E quinone is a potent anticoagulant. This observation may have significance for field trials in which vitamin E is observed to exhibit beneficial effects on ischemic heart disease and stroke. Vitamin E quinone is a potent inhibitor of the vitamin K-dependent carboxylase that controls blood clotting. A newly discovered mechanism for the inhibition requires attachment of the active site thiol groups of the carboxylase to one or more methyl groups on vitamin E quinone. The results from a series of model reactions support this interpretation of the anticlotting activity associated with vitamin E.
摘要
还原态的α-生育酚形式的维生素E显示出非常适度的抗凝血活性。相比之下，维生素E醌是一种有效的抗凝剂。这一观察结果可能对现场试验具有重要意义，在这些试验中，维生素E被观察到对缺血性心脏病和中风有有益影响。维生素E醌是控制血液凝固的维生素K依赖性羧化酶的有效抑制剂。一种新发现的抑制机制要求羧化酶的活性位点硫醇基团与维生素E醌上的一个或多个甲基相连。一系列模型反应的结果支持了对与维生素E相关的抗凝血活性的这种解释。
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