Helson L
Thromb Res. 1984 Jul 1;35(1):11-8. doi: 10.1016/0049-3848(84)90308-6.
During a Phase I study of intravenous vitamin E-free alcohol (all-rac-alpha-tocopherol or Ephynal) in patients with neuroblastoma, we noticed a bleeding diathesis in two patients receiving 2300 mg/m2 daily for four or more days in succession. Both blood prothrombin time and accelerated partial thromboplastin times were prolonged. These spontaneously returned to normal levels three days after interrupting vitamin E infusions. It was also noted that factors VII, IX and X were decreased, which corresponded with the prolonged PT and APTT. It was found that by infusing menadiol sodium diphosphate just prior to the vitamin E, these inhibiting effects on procoagulant factors could be abrogated and high dosages of vitamin E-free alcohol safely given.
在一项针对神经母细胞瘤患者的静脉注射无维生素E酒精（消旋α-生育酚或维生素E醋酸酯）的I期研究中，我们注意到两名患者连续四天或更长时间每天接受2300 mg/m²的剂量后出现了出血倾向。凝血酶原时间和活化部分凝血活酶时间均延长。在中断维生素E输注三天后，这些指标自发恢复到正常水平。还注意到因子VII、IX和X减少，这与凝血酶原时间和活化部分凝血活酶时间延长相一致。结果发现，在维生素E之前输注磷酸甲萘氢醌，可以消除对促凝血因子的这些抑制作用，并安全地给予高剂量的无维生素E酒精。
