果蝇双胸复合体的完整序列。
Complete sequence of the bithorax complex of Drosophila.
作者信息
Martin C H, Mayeda C A, Davis C A, Ericsson C L, Knafels J D, Mathog D R, Celniker S E, Lewis E B, Palazzolo M J
机构信息
Human Genome Center, Lawrence Berkeley Laboratory, Berkeley, CA 94720, USA.
出版信息
Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8398-402. doi: 10.1073/pnas.92.18.8398.
The bithorax complex (BX-C) of Drosophila, one of two complexes that act as master regulators of the body plan of the fly, is included within a sequence of 338,234 bp (SEQ89E). This paper presents the strategy used in sequencing SEQ89E and an analysis of its open reading frames. The BX-C sequence (BXCALL) contains 314,895 bp obtained by deletion of putative genes that are located at each end of SEQ89E and appear to be functionally unrelated to the BX-C. Only 1.4% of BXCALL codes for the three homeodomain-containing proteins of the complex. Principal findings include a putative ABD-A protein (ABD-AII) larger than a previously known ABD-A protein and a putative glucose transporter-like gene (1521 bp) located at or near the bithoraxoid (bxd), infra-abdominal-2 (iab-2) boundary on the opposite strand relative to that of the homeobox-containing genes.
果蝇的双胸复合体（BX-C）是调控果蝇身体结构的两个主要复合体之一，包含在一段338,234 bp的序列（SEQ89E）中。本文介绍了对SEQ89E进行测序所采用的策略及其开放阅读框分析。BX-C序列（BXCALL）包含314,895 bp，是通过删除SEQ89E两端推测的基因获得的，这些基因似乎与BX-C在功能上无关。BX-C序列中仅有1.4%编码该复合体的三种含同源结构域的蛋白质。主要发现包括一种推测的ABD-A蛋白（ABD-AII），其比先前已知的ABD-A蛋白更大，以及一个推测的葡萄糖转运蛋白样基因（1521 bp），该基因位于同源异型框基因相反链上的双胸样（bxd）、腹下-2（iab-2）边界处或附近。
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