Agzamova R T, Zaslavskaia R M, Teĭblium M M, Perepelkin E G
Ter Arkh. 1995;67(6):54-7.
The efficacy of conventional treatment (CT) in 20 controls was compared to that of heparin chronotherapy (HC) in 40 patients with chronic pyelonephritis. The results were indicative of the advantages of HC when heparin was given at the time of maximal clotting activity and platelet aggregation over CT when heparin daily dose was divided into 4 portions 5000 U each. A persistent clinical and laboratory effect with a pronounced trend to normalization of chronostructure of hemocoagulation circadian rhythms became evident on day 19 in patients on CT and on day 14 on HC. Side effects in CT appeared less frequent.
将20名对照患者的传统治疗（CT）疗效与40名慢性肾盂肾炎患者的肝素时间疗法（HC）疗效进行了比较。结果表明，当在最大凝血活性和血小板聚集时给予肝素时，HC比将肝素每日剂量分为4份、每份5000 U的CT更具优势。在接受CT治疗的患者中，第19天出现持续的临床和实验室效应，血液凝固昼夜节律的时间结构有明显的正常化趋势；在接受HC治疗的患者中，第14天出现这种趋势。CT的副作用出现频率较低。
