[The efficacy of heparin chronotherapy in patients with chronic pyelonephritis].

The efficacy of conventional treatment (CT) in 20 controls was compared to that of heparin chronotherapy (HC) in 40 patients with chronic pyelonephritis. The results were indicative of the advantages of HC when heparin was given at the time of maximal clotting activity and platelet aggregation over CT when heparin daily dose was divided into 4 portions 5000 U each. A persistent clinical and laboratory effect with a pronounced trend to normalization of chronostructure of hemocoagulation circadian rhythms became evident on day 19 in patients on CT and on day 14 on HC. Side effects in CT appeared less frequent.