Rubens R D, Knight R K, Hayward J L
Br J Cancer. 1975 Dec;32(6):730-6. doi: 10.1038/bjc.1975.284.
Ninety-nine patients with advanced breast cancer were randomized to receive either cyclophosphamide continuously or a combination of cyclophosphamide, methotrexate, 5-fluorouracil and vinblastine given intermittently. The number and duration of objective responses were greater in patients receiving the combination but the differences between the two treatments did not achieve formal significance. The combination was logistically easier to manage and produced less toxicity.
99例晚期乳腺癌患者被随机分组，分别接受持续环磷酰胺治疗或环磷酰胺、甲氨蝶呤、5-氟尿嘧啶和长春花碱间歇联合治疗。接受联合治疗的患者客观缓解的数量和持续时间更多，但两种治疗方法之间的差异未达到统计学显著性。联合治疗在组织实施上更易管理，且毒性更小。
