Brown W G, Hasan F M, Barbee R A
JAMA. 1978 May 12;239(19):2012-4. doi: 10.1001/jama.239.19.2012.
The use of bleomycin sulfate as an antineoplastic agent has been limited by its substantial pulmonary toxic effects. The exact incidence and prognosis of bleomycin-pneumonitis is unresolved. Although bleomycin pulmonary toxicity is thought to be dose-related, recent reports have emphasized severe reactions at low doses. Furthermore, severe pulmonary toxicity has been suggested to be progressive, irreversible, and ultimately, fatal. We report clinical, roentgenographic, and pathophysiologic recovery after severe, bleomycin-induced pneumonitis.
硫酸博来霉素作为一种抗肿瘤药物的使用，一直受到其严重肺部毒性作用的限制。博来霉素肺炎的确切发病率和预后尚无定论。尽管博来霉素肺部毒性被认为与剂量相关，但最近的报告强调了低剂量时的严重反应。此外，严重肺部毒性被认为是进行性的、不可逆的，最终会导致死亡。我们报告了严重的博来霉素诱导性肺炎后的临床、影像学和病理生理学恢复情况。
