肿瘤坏死因子α基因多态性与类风湿关节炎无关。
A tumour necrosis factor alpha polymorphism is not associated with rheumatoid arthritis.
作者信息
Wilson A G, de Vries N, van de Putte L B, Duff G W
机构信息
University Department of Medicine, University of Sheffield, Royal Hallamshire Hospital, United Kingdom.
出版信息
Ann Rheum Dis. 1995 Jul;54(7):601-3. doi: 10.1136/ard.54.7.601.
Abstract
OBJECTIVE
To determine whether a polymorphism within the tumour necrosis factor alpha (TNF alpha) gene is associated with susceptibility to, or severity of, rheumatoid arthritis (RA).
METHODS
Consecutive patients with recent onset RA were enrolled in a prospective trial. DNA was collected, disease activity was measured at presentation, and radiographic progression at three years was assessed. Typing of TNF alpha was by polymerase chain reaction and single stranded conformation polymorphism analysis.
RESULTS
No association of TNF alpha alleles and susceptibility to, or severity of, RA was demonstrated.
CONCLUSIONS
These results indicate that this TNF alpha polymorphism does not play a part in the genetic background of RA.
摘要
目的
确定肿瘤坏死因子α（TNFα）基因内的多态性是否与类风湿性关节炎（RA）的易感性或严重程度相关。
方法
近期发病的类风湿性关节炎患者连续纳入一项前瞻性试验。收集DNA，在就诊时测量疾病活动度，并评估三年时的影像学进展。通过聚合酶链反应和单链构象多态性分析对TNFα进行分型。
结果
未证明TNFα等位基因与类风湿性关节炎的易感性或严重程度有关。
结论
这些结果表明，这种TNFα多态性在类风湿性关节炎的遗传背景中不起作用。
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