Di Giovine F S, Nuki G, Duff G W
University of Edinburgh Department of Medicine, UK.
Ann Rheum Dis. 1988 Sep;47(9):768-72. doi: 10.1136/ard.47.9.768.
The actions of tumour necrosis factor (TNF) include resorption of bone and cartilage, suggesting a potential role in the pathogenesis of arthritis. TNF activity was looked for in synovial fluids from 137 patients with different rheumatic diseases. Unfractionated samples were tested in the L929 bioassay. Significant TNF activity that was neutralised by monoclonal antibody to TNF alpha occurred in 13 (30%) of 44 samples. Raised TNF levels were not associated with any particular disease type or routine laboratory markers of inflammation but were related to disease duration in osteoarthritis. The finding of biologically active TNF in symptomatic joints of arthritic patients supports the idea that it may contribute to the pathogenesis of joint damage in chronic rheumatic diseases.
肿瘤坏死因子(TNF)的作用包括骨质和软骨的吸收,提示其在关节炎发病机制中可能发挥作用。对137例患有不同风湿性疾病患者的滑液进行了TNF活性检测。未分级的样本采用L929生物测定法进行检测。44份样本中有13份(30%)出现了被抗TNFα单克隆抗体中和的显著TNF活性。TNF水平升高与任何特定疾病类型或炎症的常规实验室指标均无关联,但与骨关节炎的病程有关。在关节炎患者有症状的关节中发现具有生物活性的TNF,支持了其可能在慢性风湿性疾病关节损伤发病机制中起作用的观点。