肉芽肿性血管炎中的妊娠情况。
Pregnancy in granulomatous vasculitis.
作者信息
Lima F, Buchanan N, Froes L, Kerslake S, Khamashta M A, Hughes G R
机构信息
Lupus Pregnancy Clinic, St Thomas's Hospital, London, United Kingdom.
出版信息
Ann Rheum Dis. 1995 Jul;54(7):604-6. doi: 10.1136/ard.54.7.604.
Abstract
OBJECTIVE
To study the fetal and maternal outcome of pregnancy in patients with granulomatous vasculitis.
METHODS
Four pregnancies in two patients with Wegener's granulomatosis (WG) and one patient with Churg-Strauss syndrome (CSS) were identified and followed in our specialised clinic for pregnancy and connective tissue diseases.
RESULTS
Three pregnancies ended with live babies and one with intrauterine death at 25 weeks of gestation. One WG patient remained in remission throughout pregnancy and the other experienced severe activity at 12 weeks. The CSS patient was in remission during her first pregnancy, but the disease flared severely in the second.
CONCLUSIONS
Pregnancy in patients with granulomatous vasculitis requires preconceptual planning, careful clinical management, and vigorous treatment of active disease.
摘要
目的
研究肉芽肿性血管炎患者的胎儿及母体妊娠结局。
方法
在我们的妊娠与结缔组织病专科门诊中，识别并随访了2例韦格纳肉芽肿（WG）患者和1例变应性肉芽肿性血管炎（CSS）患者的4次妊娠情况。
结果
3次妊娠以活产告终，1次妊娠在孕25周时发生宫内死亡。1例WG患者在整个孕期病情缓解，另1例在孕12周时病情严重活动。CSS患者在首次妊娠期间病情缓解，但在第二次妊娠时病情严重复发。
结论
肉芽肿性血管炎患者妊娠需要孕前规划、仔细的临床管理以及对活动期疾病进行积极治疗。
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